Restylane is a family of dermal fillers, and each product is approved for different areas. The FDA's approval record lists the products and the year each use was approved.1 Ask which Restylane product is offered and whether it is approved for the area.
Here is what the record lists by use, how long hyaluronic acid fillers last and the risks. It gives no dose and no technique. Whether to have filler is for you and a clinician.
What the FDA record lists
The first Restylane was approved in 2005 for moderate to severe facial wrinkles and folds, such as nasolabial folds. Lip augmentation was added in 2011.1 Perlane followed in 2007 for deeper folds and wrinkles. Restylane Lyft was approved in 2015 for folds and wrinkles and for cheek augmentation and midface contour, and later for the chin, in 2025.1
Restylane products and uses, from the FDA record
- Restylane and Restylane-L, Perlane: moderate to severe facial wrinkles and folds; lip augmentation for Restylane
- Restylane Silk and Restylane Kysse: lip augmentation and lines around the mouth
- Restylane Refyne and Defyne: facial wrinkles and folds, Defyne for deep ones; Defyne also for the chin
- Restylane Lyft: folds and wrinkles, cheek augmentation and midface contour, and the chin
- Restylane Contour: cheek augmentation and midface contour, and temple hollowing
- Restylane Eyelight: hollows under the eyes
Restylane Silk was approved in 2014, and Kysse in 2020, for lips and the lines around the mouth. Refyne and Defyne were approved in 2016. Defyne's chin use came in 2021.1 Restylane Contour was approved in 2021 for the cheeks and in March 2026 for temple hollowing. In September 2026 its labeling added that, for temple hollowing, it is distributed only to providers who completed device-specific training.1 Restylane Eyelight was approved in 2023 for improving hollowing under the eyes.1
The record's age wording is "over the age of 21" for these products, which the FDA's consumer update gives as 22 and older.3 Our pages on cheek filler, lip filler and under-eye filler go through those areas.
How long it lasts
Restylane is a hyaluronic acid filler. The FDA says hyaluronic acid is a sugar found in body tissues such as skin and cartilage, that some is chemically modified (crosslinked) to last longer, and that the effects last approximately 6 to 12 months.2 The injections may need repeating to keep the effect.3 Our comparison of Juvederm and Restylane sets the two families side by side.
Myth
Restylane is one product that works for every area.
Fact
It is a family of products, each approved for specific uses. The FDA's record lists different Restylane products for wrinkles, lips, cheeks, chin, under-eye hollows and temples.
Risks
Common risks are bruising, redness, swelling, pain, tenderness, itching and rash. Most appear shortly after injection and many resolve in days to weeks.3 The most serious risk is accidental injection into a blood vessel, which the FDA says can cause skin necrosis (death of tissue), stroke or blindness. The chance is low, but the complications can be serious and may be permanent.3 Reducing or removing filler may need further injections or surgery.3
What med spas name
872 of the 7,475 med spas we list name Restylane among their brands. Naming a brand doesn't tell you which product they use or for which area, so ask.4
Which licensed professionals may inject depends on your state. See our guide to choosing a lip filler provider, whose checks apply to any filler.
Here is what to bring to a consultation.
Questions to bring
The product
The person and the plan
Cost
We don't give prices on this page. Our lip filler cost guide shows how clinics quote filler, per syringe.
Find clinics
Each listing shows what the clinic’s own website offers, its Google reviews and its hours. No clinic is graded yet.
Common questions
What is Restylane approved for?
It depends on the product. The FDA's record lists wrinkles and folds, lip augmentation and lines around the mouth, cheek augmentation, chin augmentation, hollows under the eyes and temple hollowing, each for specific Restylane products.
How long does Restylane last?
The FDA says hyaluronic acid fillers last approximately 6 to 12 months. It depends on the area and the product.
Is Restylane the same as Juvederm?
They are separate families of hyaluronic acid fillers, each with its own approvals. See our comparison for how they differ.
What is the biggest risk of Restylane?
Accidental injection into a blood vessel. The FDA says it can cause tissue death, stroke or blindness. The chance is low, but the complications can be serious and permanent.
Sources (4)
- FDA PMA database: Restylane family (P040024, P140029), approval and supplement history · US Food and Drug Administration, premarket approval database. Read on 30 Oct 2026: the approval statements on 133 entries for P040024 and 52 for P140029, not the product labeling. · read 30 Oct 2026
- FDA, FDA-Approved Dermal Fillers · US Food and Drug Administration, medical devices page (content current as of 11/09/2020 per the page) · read 30 Oct 2026
- FDA, Dermal Filler Do's and Don'ts for Wrinkles, Lips and More · US Food and Drug Administration (content current as of 07/07/2023 per the page) · read 30 Oct 2026
- Clinic websites: what they say on their own pages · Our own read of listed clinics' websites in the 14 states we cover, October 2026. A clinic counts once. · read 30 Oct 2026